Bioeconomy Institute

Chemical Methodologies and Library Development

This project is part of the University of Kansas Center of Excellence in Chemical Methodologies & Library Development (KU-CMLD), which is funded by the Chemical Methodologies and Library Development (CMLD) initiative.

The CMLD has established centers whose mission is to develop efficient, general, state-of-the-art methodologies for the design, synthesis, analysis, and handling of chemical diversity libraries. The goals of the program are to discover and to implement fundamental new chemistry that will facilitate access to high-quality libraries of expanded diversity. Each center hosts a library synthesis core facility that serves two purposes: to validate newly developed methodologies for application to diversity-oriented synthesis, and to apply newly developed chemical methodologies and strategies to the generation of chemical diversity libraries for high-throughput biological screening.

At the University of Kansas Center, the goal is to design and synthesize libraries that (1) utilize new principles of scaffold design (and especially the incorporation of multiple scaffold cores into a single library), (2) are likely to have pharmacological activity based on sound drug design principles, and (3) are likely to have drug-like characteristics. The work at the KU-CMLD involves 15 researchers located at the University of Kansas, the University of Missouri-Kansas City, Iowa State University, and Deciphera Pharmaceuticals.

Iowa State University is engaging in this project in the area of organometallic combinatorial chemistry. Researchers are focusing on the design of a recyclable, chiral palladium(0)-based linker/scaffold; developing solid-supported palladium(II) and platinum(II) catalysts for electrophilic activation and subsequent functional elaboration of aromatic C-H bonds; and developing a novel, highly practical and general iodocyclication protocol for the generation of an array of 1-iodo-2-aryl-substituted heterocycles.

Principal Investigator:

Richard Larock, Iowa State University

Associated Contracts or Grants:

Chemical Methodologies and Library Development (University of Kansas)

Participating and/or Sponsoring Organizations:

University of Kansas
National Institute of General Medical Sciences